Vasopressin Receptor
The neurohypophysial hormone arginine vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of vasopressin receptors, designated V1a, V1b (or V3), and V2. They all belong to the large rhodopsin-like G-protein-coupled receptor family.
The V1a receptor is expressed in both neuronal and non-neuronal tissues including the heart and elicits a variety of physiological effects including cell contraction and proliferation, stimulation of hepatic glycogenolysis, platelet aggregation and coagulation factor release. The V1b receptor subtype is found predominantly in the pituitary gland where it stimulates adrenocorticotropic hormone release. Both the V1a and V1b AVP receptors act through a G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) to activate phospholipase C-β, and, thus enhance cellular IP3 and calcium levels. By contrast, the V2 receptor subtype is localized predominantly to the kidney where it mediates the anti-diuretic effects of AVP through the heterotrimeric G protein Gs and activation of adenylyl cyclase.
Vasopressin Receptor Isoform Specific Products
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Vasopressin Receptor Inhibitors
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Vasopressin Receptor Agonists
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Vasopressin Receptor Antagonists
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Vasopressin Receptor Activators
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Vasopressin Receptor Modulator
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Vasopressin Receptor Control
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Vasopressin Receptor Ligand
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Vasopressin Receptor Related Products (127)
Related Products (127)
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Vasopressin Receptor Isoform Comparison
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Kalata B7
0 ImagesCat. No.: HY-P10325CAS No.: 339532-29-5Kalata B7 is a cyclotide that can be isolated from Oldenlandia affinis DC (Rubiaceae) and possesses membrane-permeating capabilities. Kalata B7 is also a partial agonist of oxytocin and vasopressin V1a receptors.
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Pneumadin, rat
0 ImagesCat. No.: HY-P1747CAS No.: 130918-90-0Synonyms: PNMPneumadin, rat (PNM) is a decapeptide, which possess a potent stimulating effect on arginine-vasopressin (AVP) release. Pneumadin, rat (PNM) exerts a marked antidiuretic effect in animals with functional AVP system.
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5,6-DHET
0 ImagesCat. No.: HY-113132CAS No.: 213382-49-15,6-DHET is a regioisomer of vic-dihydroxyeicosatrienoic acid and also inhibitor of the hydroosmotic effect of arginine vasopressin.
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Atosiban (Standard)
0 ImagesCat. No.: HY-17572RCAS No.: 90779-69-4Synonyms: RW22164 (Standard); RWJ22164 (Standard)Atosiban (Standard) is the analytical standard of Atosiban. This product is intended for research and analytical applications. Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.
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Conivaptan
0 ImagesCat. No.: HY-18347CAS No.: 210101-16-9Synonyms: YM 087 free baseConivaptan (YM 087 free base) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan is used for research on hyponatremia and congestive heart failure.
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SRX246 (Standard)
0 ImagesCat. No.: HY-105685RCAS No.: 512784-93-9SRX246 (Standard) is the analytical standard of SRX246 (HY-105685). This product is intended for research and analytical applications. SRX246 is a potent, BBB-penetrant, highly selective vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders.
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L-364918
0 ImagesCat. No.: HY-129333CAS No.: 122211-31-8L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance.
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Mozavaptan hydrochloride (Standard)
0 ImagesSynonyms: OPC-31260 hydrochloride (Standard)Mozavaptan (hydrochloride) (Standard) is the analytical standard of Mozavaptan (hydrochloride). This product is intended for research and analytical applications. Mozavaptan hydrochloride (OPC-31260 hydrochloride) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan hydrochloride shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan hydrochloride has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment.
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(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin
0 ImagesCat. No.: HY-P5006CAS No.: 176714-12-8Synonyms: d(CH2)5[Tyr(Me)2, Dab5]AVP(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) is a specific antagonist of vasopressin V1a receptor, with a pA2 of 6.71.
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Bromotubercidin
0 ImagesCat. No.: HY-W130132CAS No.: 21193-80-6Bromotubercidin is a RNA synthesis inhibitor. Bromotubercidin induces biphasic decreases in vasopressin biosynthesis and causes progressive reduction in vasopressin biosynthesis.
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RWJ-676070
0 ImagesCat. No.: HY-19880CAS No.: 813426-25-4RWJ-676070 is a dual vasopressin V(1A)/V(2) receptor antagonist with an Ki value of 1.4 nM and 14 nM respectly.
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OT-R agonist 1 TFA
0 ImagesCat. No.: HY-172814ACAS No.: 3039925-73-7OT-R agonist 1 TFA (compound 5) is an oxytocin receptor agonist with an EC50 of 0.39 nM. OT-R agonist 1 TFA shows V1A antagonist activity with an EC50 of 2432 nM and can be used for study of CNS disorders.
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YM218 free base
0 ImagesCat. No.: HY-118918CAS No.: 387816-81-1YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease.
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Mozavaptan (Standard)
0 ImagesSynonyms: OPC-31260 (Standard)Mozavaptan (Standard) is the analytical standard of Mozavaptan. This product is intended for research and analytical applications. Mozavaptan (OPC-31260) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment.
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Lixivaptan (Standard)
0 ImagesSynonyms: VPA-985 (Standard); WAY-VPA 985 (Standard)Lixivaptan (Standard) is the analytical standard of Lixivaptan. This product is intended for research and analytical applications. Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively.
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Balovaptan (Standard)
0 ImagesCat. No.: HY-109024RCAS No.: 1228088-30-9Synonyms: RG7314 (Standard)Balovaptan (Standard) is the analytical standard of Balovaptan (HY-109024). This product is intended for research and analytical applications. Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
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(R)-(+)-Tolvaptan
0 ImagesCat. No.: HY-17000ACAS No.: 331947-66-1Synonyms: (R)-(+)-OPC-41061(R)-(+)-Tolvaptan ((R)-(+)-OPC-41061) is the (R)-(+) enantiomer of Tolvaptan (HY-17000). Tolvaptan (OPC-41061) is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist.
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Atosiban acetate (Standard)
0 ImagesCat. No.: HY-17572ARCAS No.: 914453-95-5Synonyms: RW22164 acetate (Standard); RWJ22164 acetate (Standard)Atosiban (acetate) (Standard) is the analytical standard of Atosiban (acetate). This product is intended for research and analytical applications. Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.
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(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
0 ImagesCat. No.: HY-P1162CAS No.: 73168-24-8Synonyms: SKF 100273(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist.
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Selepressin (Standard)
0 ImagesCat. No.: HY-105239RCAS No.: 876296-47-8Synonyms: FE 202158 (Standard)Selepressin (Standard) is the analytical standard of Selepressin (HY-105239). This product is intended for research and analytical applications. Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock.
